These four brothers got their start singing in the church choir as children. After his discharge from the army in the early 1960s, George Chambers relocated to Los Angeles. His brothers followed and they soon became mainstays on the gospel circuit.
Like many of their contemporaries in the acoustic-based gospel and folk scenes, The Chambers Brothers electrified their sound in the mid-60s, which led to a record deal and a commercial breakthrough with the 1968 release of "Time Has Come Today". Despite their strong musical output, the band broke up in 1972, just a year after appearing at the Celebration of Life.